Indications and usage
Intramuscular penicillin G benzathine is indicated in the treatment of
infections due to penicillin-G-sensitive microorganisms that are
susceptible to the low and very prolonged serum levels common to this
particular dosage form. Therapy should be guided by bacteriological
studies (including sensitivity tests) and by clinical response.
The following infections will usually respond to adequate dosage of intramuscular penicillin G benzathine:
Mild-to-moderate infections of the upper respiratory tract due to susceptible streptococci Venereal infections —syphilis, yaws, bejel, and pintaMedical conditions in which penicillin G benzathine therapy is indicated as prophylaxis:
Rheumatic fever and/or chorea —prophylaxis
with penicillin G benzathine has proven effective in preventing
recurrence of these conditions. It has also been used as follow-up
prophylactic therapy for rheumatic heart disease and acute
glomerulonephritis. DOSAGE AND ADMINISTRATION
PATIENT TYPE STAGE DOSE
Adult Primary, secondary, and early latent (< year)
2.4 million units intramuscular (IM), single dose
Adult Late latent (>1 year) or latent syphilis of unknown duration and tertiary syphilis (either cardiovascular or gummatous)
7.2 million units, administered as 3 doses of 2.4 million units IM each week at 1-week intervals
Pediatric Primary, secondary, and early latent (<1 year)
50,000 units/kg IM, up to the adult dose of 2.4 million units in a single dose
Pediatric Acquired syphilis in the late latent stage, with normal cerebrospinal fluid results
50,000
units/kg IM, up to the adult dose of 2.4 million units in a single
dose, administered as 3 doses at 1-week intervals (total dose of
150,000 units/kg up to the adult total dose of 7.2 million units)
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